Strain: NOD.Cg-Prkdc^scid/JInv

Common name: NOD SCID

JAX stock no. 001303

Mice homozygous for the severe combined immune deficiency spontaneous mutation Prkdc^scid, commonly referred to as scid, are characterized by an absence of functional T cells and B cells, lymphopenia, hypogammaglobulinemia, and a normal hematopoietic microenvironment. Prkdc^scid mice accept allogeneic and xenogeneic grafts making them an ideal model for cell transfer experiments. In general, Prkdc^scid leakiness is low on the NOD/ShiLtSz genetic background.

Disease/therapeutics areas used:

• Cancer research
  • B and T cell deficiency, xenograft/transplant host
• Immunology, Inflammation and Autoimmunity Research
  • B and T cell deficiency
• Internal/Organ Research
  • Lymphoid Tissue Defects
• Virology Research
  • B and T Cell Deficiency- AIDS research tool
• Diabetes and Obesity Research
  • Islet Transplantation Studies

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